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Arch Iran Med. 2024;27(7): 350-356.
doi: 10.34172/aim.28887
PMID: 39072382
PMCID: PMC11316182
Scopus ID: 85199936708
  Abstract View: 615
  PDF Download: 477

Original Article

Causes of Colectomy in Patients with Ulcerative Colitis: Findings from an Iranian National Registry

Zahra Momayez Sanat 1 ORCID logo, Homayoon Vahedi 1, Reza Malekzadeh 1, Amir Kasaeian 2,3,4, Negar Mohammadi Ganjaroudi 5, Alireza Sima 6, Fariborz Mansour Ghanaei 7, Mohammadreza Ghadir 8, Hafez Tirgar Fakheri 9, Siavosh Nasseri Moghaddam 1, Sudabeh Alatab 1* ORCID logo, Anahita Sadeghi 1, Amir Anushiravani 1, Iradj Maleki 9, Abbas Yazdanbod 10, Hassan Vossoughinia 11, Mohammadreza Seyyedmajidi 12, Sayed Jalaleddin Naghshbandi 13, Nadieh Baniasadi 14, Baran Parhizkar 13, Saied Matinkhah 15, Shahsanam Gheibi 16, Roya-sadat Hosseini Hemmat Abadi 17, Seyedmohamad Valizadeh Toosi 9

1 Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
2 Digestive Oncology Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
3 Research Center for Chronic Inflammatory Diseases, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
4 Clinical Research Development Unit, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
5 School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6 Sasan Alborz Biomedical Research Center, Masoud Gastroenterology and Hepatology Center, Tehran, Iran
7 Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Guilan, Iran
8 Gastroenterology and Hepatology Diseases Research Center, Qom University of Medical Science, Qom, Iran
9 Gut and Liver Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
10 Digestive Diseases Research Center, Ardabil University of Medical Sciences, Ardabil, Iran
11 Department of Gastroenterology and Hepatology, Mashhad University of Medical Sciences, Mashhad, Iran
12 Golestan Research Center of Gastroenterology, Golestan University of Medical Science, Gorgan, Iran
13 Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
14 Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran
15 Isfahan University of Medical Sciences, Isfahan, Iran
16 Maternal and Childhood Obesity Research center, Urmia University of Medical Sciences, Urmia, Iran
17 Shahid Sadoughi University, Yazd, Iran
*Corresponding Author: Sudabeh Alatab, Email: sudabehalatab@yahoo.com

Abstract

Background: Ulcerative colitis (UC) is a form of inflammatory bowel disease (IBD) marked by rectal and colon inflammation, leading to relapsing symptoms. Its prevalence is increasing, particularly in developed nations, impacting patients’ health. While its exact cause remains unclear, genetic and environmental factors are implicated, elevating the risk of colorectal cancer (CRC). Colectomy, though declining, is still performed in select UC cases, necessitating further study.

Methods: We analyzed data from the Iranian Registry of Crohn’s and Colitis (IRCC) to examine UC patients undergoing colectomy. We collected demographic and clinical data from 91 patients, focusing on dysplasia. Statistical analyses assessed dysplasia risk factors.

Results: Patients with dysplasia were older at diagnosis and surgery compared to those without dysplasia. Age emerged as a significant risk factor for dysplasia in UC patients undergoing colectomy. No significant associations were found between dysplasia and other factors.

Conclusion: Age plays a crucial role in dysplasia risk among UC patients undergoing colectomy. Older age at diagnosis and surgery may indicate a higher risk of dysplasia and CRC. Clinicians should consider age when managing UC patients and implementing screening protocols. Further research with larger samples is needed to confirm these findings.


Cite this article as: Momayez Sanat Z, Vahedi H, Malekzadeh R, Kasaeian A, Mohammadi Ganjaroudi N, Sima A, et al. Causes of Colectomy in Patients with Ulcerative Colitis: Findings from an Iranian National Registry. Arch Iran Med. 2024;27(7):350-356. doi: 10.34172/aim.28887
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Submitted: 02 Feb 2024
Accepted: 05 Jun 2024
ePublished: 01 Jul 2024
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