Zahra Momayez Sanat
1 
, Homayoon Vahedi
1, Reza Malekzadeh
1, Amir Kasaeian
2,3,4, Negar Mohammadi Ganjaroudi
5, Alireza Sima
6, Fariborz Mansour Ghanaei
7, Mohammadreza Ghadir
8, Hafez Tirgar Fakheri
9, Siavosh Nasseri Moghaddam
1, Sudabeh Alatab
1* , Anahita Sadeghi
1, Amir Anushiravani
1, Iradj Maleki
9, Abbas Yazdanbod
10, Hassan Vossoughinia
11, Mohammadreza Seyyedmajidi
12, Sayed Jalaleddin Naghshbandi
13, Nadieh Baniasadi
14, Baran Parhizkar
13, Saied Matinkhah
15, Shahsanam Gheibi
16, Roya-sadat Hosseini Hemmat Abadi
17, Seyedmohamad Valizadeh Toosi
91 Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
2 Digestive Oncology Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
3 Research Center for Chronic Inflammatory Diseases, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
4 Clinical Research Development Unit, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
5 School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6 Sasan Alborz Biomedical Research Center, Masoud Gastroenterology and Hepatology Center, Tehran, Iran
7 Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Guilan, Iran
8 Gastroenterology and Hepatology Diseases Research Center, Qom University of Medical Science, Qom, Iran
9 Gut and Liver Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
10 Digestive Diseases Research Center, Ardabil University of Medical Sciences, Ardabil, Iran
11 Department of Gastroenterology and Hepatology, Mashhad University of Medical Sciences, Mashhad, Iran
12 Golestan Research Center of Gastroenterology, Golestan University of Medical Science, Gorgan, Iran
13 Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
14 Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran
15 Isfahan University of Medical Sciences, Isfahan, Iran
16 Maternal and Childhood Obesity Research center, Urmia University of Medical Sciences, Urmia, Iran
17 Shahid Sadoughi University, Yazd, Iran
Abstract
Background: Ulcerative colitis (UC) is a form of inflammatory bowel disease (IBD) marked by rectal and colon inflammation, leading to relapsing symptoms. Its prevalence is increasing, particularly in developed nations, impacting patients’ health. While its exact cause remains unclear, genetic and environmental factors are implicated, elevating the risk of colorectal cancer (CRC). Colectomy, though declining, is still performed in select UC cases, necessitating further study.
Methods: We analyzed data from the Iranian Registry of Crohn’s and Colitis (IRCC) to examine UC patients undergoing colectomy. We collected demographic and clinical data from 91 patients, focusing on dysplasia. Statistical analyses assessed dysplasia risk factors.
Results: Patients with dysplasia were older at diagnosis and surgery compared to those without dysplasia. Age emerged as a significant risk factor for dysplasia in UC patients undergoing colectomy. No significant associations were found between dysplasia and other factors.
Conclusion: Age plays a crucial role in dysplasia risk among UC patients undergoing colectomy. Older age at diagnosis and surgery may indicate a higher risk of dysplasia and CRC. Clinicians should consider age when managing UC patients and implementing screening protocols. Further research with larger samples is needed to confirm these findings.