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Arch Iran Med. 2024;27(5): 229-238.
doi: 10.34172/aim.2024.34
  Abstract View: 264
  PDF Download: 130

Original Article

Infective Endocarditis in North Africa and the Middle East, 1990‒2019: Updates from the Global Burden of Disease Study 2019

Elaheh Malakan Rad 1 ORCID logo, Sara Momtazmanesh 2,3 ORCID logo, Sahar Saeedi Moghaddam 3,4 ORCID logo, Negar Rezaei 3,5 ORCID logo, Nazila Rezaei 3 ORCID logo, Hamidreza Jamshidi 6,7, Mohsen Naghavi 8,9, Bagher Larijani 5 ORCID logo, Farshad Farzadfar 3,5* ORCID logo, GBD 2019 NAME Endocarditis Collaborators

1 Department of Pediatric Cardiology, Tehran University of Medical Sciences, Tehran, Iran
2 School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3 Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
4 Kiel Institute for the World Economy, Kiel, Germany
5 Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
6 Department of Pharmacology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
7 Ministry of Health and Medical Education, Tehran, Iran
8 Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA
9 Department of Health Metrics Sciences, School of Medicine, University of Washington, Seattle, WA, USA
*Corresponding Author: Farshad Farzadfar, Email: f-farzadfar@tums.ac.ir

Abstract

Background: Infective endocarditis (IE), a severe and economically impactful condition, lacks substantial epidemiological data in the North Africa and Middle East (NAME) region. This study focused on analyzing the trends and burden of IE in NAME from 1990 to 2019, taking into account factors like age, gender, and socio-demographic index (SDI).

Methods: The Global Burden of Disease data from 1990 to 2019 was retrieved from the Institute for Health Metrics and Evaluation (IHME) website.

Results: Between 1990 and 2019, the age-standardized rates (ASR) for IE incidence increased by 59%, and prevalence and years lived with disability (YLDs) rose by 12% and 9%, respectively, while the ASRs for deaths, disability-adjusted life years (DALYs), and years of life lost (YLLs) saw reductions of 22%, 34%, and 34% in the NAME region. Death rates among children under five declined by 72%. Gender and the SDI did not significantly influence these changes. Saudi Arabia witnessed the most significant increase in ASR of IE incidence since 1990, while Turkey had the highest rates in 2019. The year 2019 also saw the highest death rate among those aged 70 and over, with over 91000 DALYs from IE. DALYs decreased by 71.5% for children under five from 1990 to 2019 but remained stable for individuals in their seventies. Jordan showed the most notable decrease in ASRs for deaths, DALYs, and YLLs among children under five.

Conclusion: This study highlights the changing epidemiology of IE in the NAME region, recommending the establishment of multidisciplinary IE registries, antibiotic prophylaxis guidelines for healthcare-associated IE, and strategies to control antimicrobial resistance as key mitigation measures.


Cite this article as: Malakan Rad E, Momtazmanesh S, Saeedi Moghaddam S, Rezaei N, Rezaei N, GBD 2019 NAME Endocarditis Collaborators, Jamshidi H, et al. Infective endocarditis in North Africa and the Middle East, 1990‒2019: updates from the Global Burden of Disease study 2019. Arch Iran Med. 2024;27(5):229-238. doi: 10.34172/aim.2024.34
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Submitted: 27 Jan 2024
Accepted: 09 Mar 2024
ePublished: 01 May 2024
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