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Arch Iran Med. 2023;26(10): 592-599. doi: 10.34172/aim.2023.86
PMID: 38310416        PMCID: PMC10862093

Systematic Review

Insights into Organochlorine Pesticides Exposure in the Development of Cardiovascular Diseases: A Systematic Review

Mohammad Ali Mohammadkhani 1 ORCID, Soraya Shahrzad 2, Mehrdad Haghighi 3, Reza Ghanbari 4, Ashraf Mohamadkhani 5 * ORCID

Cited by CrossRef: 1

1- Amarloei A, Noorimotlagh Z, Jaafarzadeh N, Mirzaee S. Organochlorine pesticide residues monitoring and human health risk evaluation in agricultural crops from Ilam Province, Southwest of Iran. Sci Rep. 2026;16(1) [Crossref]
2- Zhang Z, Pan Y, Fang Y, Mao S, Zhou Z, Zhang C, Song Q, Yang J, Chen R. Organochlorine pesticides: occurrence, spatial distribution of residues, toxicity, and toxic mechanisms. Toxicology. 2025;515:154134 [Crossref]
3- Chen C, Hu P, Chuang C, Chen W, Tang H, Hsu C, Lee T. The Plant Growth Regulator Forchlorfenuron (KT-30) Drives Atherosclerosis Progression via Lipid Homeostasis Disruption: Evidence from ApoE-Deficient Mice. Antioxidants. 2026;15(8):953 [Crossref]
4- Bellingham M, Evans N, Lea R, Padmanabhan V, Sinclair K. Reproductive and Metabolic Health Following Exposure to Environmental Chemicals: Mechanistic Insights from Mammalian Models. 2025;13(1):411 [Crossref]
5- Yan L, Liu Z, Zhong X, Xie B, Huang Y, Chen Q, He B, Chen F, Wang J. Exposure to organochlorine pesticides and mortality risk among individuals with diabetes: A prospective cohort analysis and network pharmacology study. Ecotoxicology and Environmental Safety. 2025;305:119274 [Crossref]
6- Muhammad H, Hanif M, Tuzen M, Siddiqui A, Kousar N, Shah A, Afshar Mogaddam M. ZnO based photocatalysts for pesticides degradation. RSC Adv. 2025;15(58):49852 [Crossref]
7- Antu M, Ahmed M, Rojoni S, Shammi S, Suraiya S, Ali M, Haq M. Exposure of Fish and Shellfish to Organochlorine Pesticides and Associated Consumer Health Risks. Environments. 2026;13(3):167 [Crossref]
8- Plantier M, Naji N, Dupont A, Hiram R. Per- and Polyfluoroalkyl Substances (PFAS) Within the Exposome: Cellular and Molecular Mechanisms Underlying a Potential Risk for Cardiac Arrhythmias and Atrial Fibrillation?. Cells. 2026;15(8):696 [Crossref]
9- Kim M, Hwang Y, Son Y, Jo Y, Kim H, Smith L, López-Gil J, Kim S, Hwang H, Yon D, Kang J. Pesticide exposure and all health outcomes: An umbrella review of meta-analyses of observational studies. Journal of Hazardous Materials. 2026;515:143013 [Crossref]
10- Sharely I, Joshi S, Maan M, Mudgil U, Verma K, Nimble A, Saini A. Human and ecological burden of pesticide contamination: Toxicological impacts, detection technologies and bioremediation. Environmental Research. 2026;306:125109 [Crossref]
11- Park H. A comprehensive review of the calcium dynamics of environmental pollutants in human health: insights from zebrafish models. Mol Cell Toxicol. 2025;21(2):399 [Crossref]
12- Wu X, Wei D, Zhou Y, Cao Q, Han G, Han E, Chen Z, Guo Y, Huo W, Wang C, Huang S, Zeng X, Wang X, Mao Z. Pesticide exposures and 10-year atherosclerotic cardiovascular disease risk: Integrated epidemiological and bioinformatics analysis. Journal of Hazardous Materials. 2025;485:136835 [Crossref]
13- Ulrich J, Jäggi L, Rüfli D, Fuhrimann S. Pesticide exposure and the risk of arterial hypertension and obesity in farm workers: a systematic review of literature. BMC Cardiovasc Disord. 2026;26(1) [Crossref]
14- Okumuş A, İçli N, Calavul A. Detection of organochlorine pesticide residues in adipose tissue obtained from individuals living in the Marmara region who underwent liposuction. Journal of Environmental Science and Health, Part B. 2026;:1 [Crossref]
15- Swati S, Soni A, Sahu V. Impact of pesticides on gonads and human health: An updated commentary. Arch Clin Toxicol. 2025;7(1):101 [Crossref]
16- Emmanuel S, Badamasi H, Sanni S, Ore O, Bayode A, Adesibikan A. A comprehensive review on photocatalytic degradation of agro‐organochlorine pollutants using multifunctional metal oxide and supported and doped metal oxide nanoarchitecture materials. J Chinese Chemical Soc. 2025;72(3):265 [Crossref]
17- He K, Chen R, Xu S, Ding Y, Wu Z, Bao M, He B, Li S. Environmental endocrine disruptor-induced mitochondrial dysfunction: a potential mechanism underlying diabetes and its complications. Front Endocrinol. 2024;15 [Crossref]
18- Geoffrey A, Ajang R, Joseph A, Ibor R, Emmanuel J, Ifon H, Saeed L. Positive Matrix Factorization reveals historical sources and combined environmental-biological transformation processes of organochlorine pesticides in Chrysichthys nigrodigitatus from the Calabar River: Implications for public health risks . Journal of Environmental Science and Health, Part A. 2026;:1 [Crossref]

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A Monthly Peer-Reviewed Medical Journal Published by the Academy of Medical Sciences of the I.R. Iran; Indexed in PubMed/MEDLINE, ISI Web of Science, EMBASE, SCOPUS, CINHAL, PASCAL, CSA, SID, ISSN: Print 1029-2977, Online 1735-3947.The impact factor of Archives of Iranian Medicine according to Journal Citation Reports® (JCR®) 2016 is 1.20.