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Arch Iran Med. 2021;24(3): 233-252. doi: 10.34172/aim.2021.35

Review Article

Prospects of Saffron and its Derivatives in Alzheimer’s Disease

Nadia Zandi 1, Benyamin Pazoki 1, Nazanin Momeni Roudsari 2, Naser-Aldin Lashgari 2, Vahid Jamshidi 2, Saeideh Momtaz 3,4,5, Amir Hossein Abdolghaffari 2,3,4,5 * , Shahin Akhondzadeh 6 *

Cited by CrossRef: 13

1- Najafabadi B, Farsinejad M, Shokraee K, Momtazmanesh S, Violette P, Esalatmanesh S, Kashani L, Jafarinia M, Akhondzadeh S. Possible effects of Saffron (Crocus sativus) in the treatment of erectile dysfunction: A randomized, double-blind, placebo-controlled trial. Journal of Herbal Medicine. 2022;32:100551 [Crossref]
2- Monteiro K, de Aquino T, da Silva-Júnior E. Natural Compounds as Inhibitors of Aβ Peptide and Tau Aggregation. CNSNDDT. 2024;23(10):1234 [Crossref]
3- Hamedani S, Pourmasoumi M, Zarifi S, Askari G, Jamialahmadi T, Bagherniya M, Sahebkar A. Therapeutic effects of saffron and its components on neurodegenerative diseases. Heliyon. 2024;10(2):e24334 [Crossref]
4- Abdian S, Fakhri S, Moradi S, Khirehgesh M, Echeverría J. Saffron and its major constituents against neurodegenerative diseases: A mechanistic review. Phytomedicine. 2024;135:156097 [Crossref]
5- Krishnan M, Kumaresan M, Ravi S, Martin L, Duraisamy P, Manikandan B, Munusamy A, Ramar M. Therapeutic potential of monoterpene molecules acts against 7KCh-mediated oxidative stress and neuroinflammatory amyloidogenic signalling pathways. Prostaglandins & Other Lipid Mediators. 2024;175:106910 [Crossref]
6- Yang W, Qiu X, Wu Q, Chang F, Zhou T, Zhou M, Pei J. Active constituents of saffron (Crocus sativus L.) and their prospects in treating neurodegenerative diseases (Review). Exp Ther Med. 2023;25(5) [Crossref]
7- Mazhar S, Shamabadi A, Kazemzadeh K, Farahvash M, Heidari Dalfard A, Fallahpour B, Khodaei Ardakani M, Akhondzadeh S. Crocus sativus (saffron) adjunct to risperidone for negative symptoms of schizophrenia: a randomized, double-blind, placebo-controlled trial. 2024; [Crossref]
8- Girme A, Saste G, Pawar S, Ghule C, Mirgal A, Patel S, Tiwari A, Ghoshal S, Bharate S, Bharate S, Reddy D, Vishwakarma R, Hingorani L. Quantitative Determination and Characterization of a Kashmir Saffron (Crocus sativus L.)-Based Botanical Supplement Using Single-Laboratory Validation Study by HPLC-PDA with LC–MS/MS and HPTLC Investigations. ACS Omega. 2021;6(36):23460 [Crossref]
9- Marrone G, Urciuoli S, Di Lauro M, Cornali K, Montalto G, Masci C, Vanni G, Tesauro M, Vignolini P, Noce A. Saffron (Crocus sativus L.) and Its By-Products: Healthy Effects in Internal Medicine. Nutrients. 2024;16(14):2319 [Crossref]
10- Ait Tastift M, Makbal R, Bourhim T, Omari Z, Isoda H, Gadhi C. Safety Assessment and Pain Relief Properties of Saffron from Taliouine Region (Morocco). Molecules. 2022;27(10):3339 [Crossref]
11- Habibi Z, Hoormand M, Banimohammad M, Ajami M, Amin G, Amin M, Pazoki-Toroudi H. The Novel Role of Crocus sativus L. in Enhancing Skin Flap Survival by Affecting Apoptosis Independent of mTOR: A Data-Virtualized Study. Aesth Plast Surg. 2022;46(6):3047 [Crossref]
12- Lashgari N, Roudsari N, Zadeh S, Momtaz S, Abbasifard M, Reiner Ž, Abdolghaffari A, Sahebkar A. Statins block mammalian target of rapamycin pathway: a possible novel therapeutic strategy for inflammatory, malignant and neurodegenerative diseases. Inflammopharmacol. 2023;31(1):57 [Crossref]
13- Kajkolah M, Nahumi A, Asgari A, Bayrami A, Asadi A, Abdolmaleki A. Protective Effects of Saffron in Nervous System Diseases: A Narrative Review. Shefaye Khatam. 2024;12(2):74 [Crossref]

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A Monthly Peer-Reviewed Medical Journal Published by the Academy of Medical Sciences of the I.R. Iran; Indexed in PubMed/MEDLINE, ISI Web of Science, EMBASE, SCOPUS, CINHAL, PASCAL, CSA, SID, ISSN: Print 1029-2977, Online 1735-3947.The impact factor of Archives of Iranian Medicine according to Journal Citation Reports® (JCR®) 2016 is 1.20.