Tanju Kapagan
1* 
, Nilufer Bulut
1 , Mehmet Halıcı
2 , Gokmen Umut Erdem
1 1 Basaksehir Cam and Sakura City Hospital, Department of Medical Oncology, 34480 Istanbul, Turkey
2 Basaksehir Cam and Sakura City Hospital, Department of Radiation Oncology, 34480 Istanbul, Turkey
Abstract
Chromophobe renal cell carcinoma (ChRCC) is a rare subtype of renal cell carcinoma (RCC). We present a case of a 61-year-old male with ChRCC who exhibited unusual metastasis to the retro-orbital area, a site rarely affected by RCC. The patient experienced diplopia and proptosis, prompting treatment with sunitinib and palliative radiotherapy. Remarkably, rapid improvement in ocular symptoms was observed following radiotherapy. Despite this localized response, the patient’s overall condition deteriorated, highlighting the aggressive nature of ChRCC. This case underscores the importance of considering ChRCC in metastatic presentations and the potential efficacy of local palliative interventions.