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Arch Iran Med. 2024;27(11): 636-638.
doi: 10.34172/aim.28846
  Abstract View: 242
  PDF Download: 208

Case Report

Hairy Cell Leukemia Following Acute Myeloid Leukemia, Concomitant or Secondary?

Zhang Bingyao 1 ORCID logo, Fu Zhaoqiang 1, Zhang Xuxi 1, Yang Qian 1, Qin Youwen 1* ORCID logo

1 Department of Clinical Laboratory, Shanghai Zhaxin Traditional Chinese and Western Medicine Hospital, Shanghai, China
*Corresponding Author: Qin Youwen, Email: youwenqin@126.com

Abstract

A 62-year-old man diagnosed with acute myeloid leukemia (AML) showed limited responses to two courses of azacitidine (AZA)+Venetoclax (VEN) therapy. Twenty days after being transferred to our hospital, flow cytometry with broad antigen coverage and mutation analysis confirmed the presence of a second malignancy, hairy cell leukemia (HCL). Following haploidentical combined umbilical cord blood transplantation, the patient achieved complete remission (CR) for both AML and HCL. This CR has been maintained for the past 14 months. Patients with dual hematologic malignancies may not respond well to conventional therapy regimens. Early initiation of hematopoietic stem cell transplantation is beneficial for improving prognosis and extending overall survival.

Cite this article as: Bingyao Z, Zhaoqiang F, Xuxi Z, Qian Y, Youwen Q. Hairy cell leukemia following acute myeloid leukemia, concomitant or secondary? Arch Iran Med. 2024;27(11):636-638. doi: 10.34172/aim.28846
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Submitted: 24 Jan 2024
Accepted: 27 Jul 2024
ePublished: 01 Nov 2024
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