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Arch Iran Med. 2022;25(10): 676-681.
doi: 10.34172/aim.2022.106
PMID: 37542399
PMCID: PMC10685871
Scopus ID: 85146846241
  Abstract View: 711
  PDF Download: 639

COVID-19

Original Article

Predictors of Mortality among COVID-19 Patients Admitted to Intensive Care Units: A Single-Center Study in Tehran, Iran

Arash Amini 1 ORCID logo, Atabak Najafi 1*, Arezoo Ahmadi 1, Mojtaba Mojtahedzadeh 2, Elahe Karimpour-Razkenari 2, Hamidreza Sharifnia 1, Shahriar Shahsavar Mistani 2, Farin Kamangar 3* ORCID logo

1 Department of Anesthesiology and Critical Care, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
3 Department of Biology, School of Computer, Mathematical, and Natural Sciences, Morgan State University, Baltimore, MD, USA
*Corresponding Authors: Corresponding Author: Atabak Najafi, MD, Email: , Email: nadjafia@tums.ac.ir; Corresponding Author: Farin Kamangar, MD, PhD; Email: , Email: farin.kamangar@morgan.edu

Abstract

Background: Iran was one of the first countries to become an epicenter of the coronavirus disease 2019 (COVID-19) epidemic. However, there is a dearth of data on the outcomes of COVID-19 and predictors of death in intensive care units (ICUs) in Iran. We collected extensive data from patients admitted to the ICUs of the one of the tertiary referral hospitals in Tehran, Iran, to investigate the predictors of ICU mortality.

Methods: The study population included 290 COVID-19 patients who were consecutively admitted to the ICUs of the Sina hospital from May 5, 2021, to December 6, 2021, a period that included the peak of the epidemic of the delta (δ) variant. Demographic data, history of prior chronic diseases, laboratory data (including markers of inflammation), radiologic data, and medication data were collected.

Results: Of the 290 patients admitted to the ICUs, 187 (64.5%) died and 103 (35.5%) survived. One hundred forty-one (141, 48.6%) were men, and the median age (10th percentile, 90th percentile) was 60 (41, 80). Using logistic regression models, older age, history of hypertension, high levels of inflammatory markers, low oxygen saturation, substantial lung involvement in computed tomography (CT) scans, and gravity of the disease as indicated by the WHO 8-point ordinal scale were primary predictors of mortality at ICU. The use of remdesivir and imatinib was associated with a statistically non-significant reduction in mortality. The use of tocilizumab had almost no effect on mortality.

Conclusion: The findings are consistent with and add to the currently existing international literature. The findings may be used to predict risk of mortality from COVID-19 and provide some guidance on potential treatments.

Keywords: COVID-19, ICU, Iran, Mortality

Cite this article as: Amini A, Najafi A, Ahmadi A, Mojtahedzadeh M, Karimpour-Razkenari E, Sharifnia H, et al. Predictors of mortality among COVID-19 patients admitted to intensive care units: a single-center study in tehran, Iran. Arch Iran Med. 2022;25(10):676-681. doi: 10.34172/aim.2022.106
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Submitted: 09 Aug 2022
Accepted: 14 Aug 2022
ePublished: 01 Oct 2022
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