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Arch Iran Med. 2015;18(10): 0.
PMID: 26443256
Scopus ID: 84943557783
  Abstract View: 2553
  PDF Download: 1692

Case Report

Acute Severe Hepatitis and Hemophagocytosis in Adult Onset Still’s Disease

Tuncay Sahutoglu*, Elif Kara, Ibrahim Oner Dogan, Mine Gulluoglu, Filiz Akyuz, Fatih Besisik
*Corresponding Author: Email: tu_cay83@yahoo.com

Abstract

We report a 44-year-old male Turkish patient with adult onset Still’s disease (AOSD) complicated by acute severe hepatitis and hemophagocytosis. Initial investigations for fever and rapidly progressive elevation of liver function tests were not diagnostic. Routine evaluations of liver and bone marrow biopsies missed the fundamental pathology. Extremely elevated ferritin levels led to a more detailed search, and immunohistochemical staining with CD68 for macrophages revealed extensive hemophagocytosis in both the first and second bone marrow biopsies, as well as in the liver biopsy. Treatment with steroid and cyclosporine A induced complete remission.

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ePublished: 01 Oct 2015
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