Academy of Medical Sciences of I.R. Iran Archives of Iranian Medicine 1029-2977 22 9 2019 09 01 Pure Androgen-Secreting Adrenocortical Carcinoma Presenting with Hypoglycemia 527 530 EN Fariba Karimi https://orcid.org/0000-0002-6107-4826 Amirreza Dehghanian Mohammadjavad Fallahi Behnam Dalfardi Journal Article 2018 12 23 2019 02 04 Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy. Most patients present with steroid hormone excess or abdominal mass effect. Pure androgen-secreting ACCs are rare, while hypoglycemia is an unusual presentation of this malignancy. We present a 26-year-old woman with hypoglycemia and history of adrenalectomy due to a large adrenal mass which was diagnosed as nonfunctional adrenal adenoma. She was admitted in our hospital 10 days after her fetal loss with repeated episodes of severe hypoglycemia. She had a high serum dehydroepiandrosterone sulfate (DHEA-S) and her hypoglycemia was associated with low insulin and C-peptide levels. Imaging revealed liver metastasis and immunohistochemical studies of the biopsied lesions confirmed the diagnosis of ACC.