Academy of Medical Sciences of I.R. Iran Archives of Iranian Medicine 1029-2977 21 12 2018 12 01 Extramedullary Manifestation of Multiple Myeloma in the Oral Cavity 611 612 EN Cristiano de Assis Pereira Hansen Jayr Schmidt Filho Marina de Mattos Nascimento Fábio Abreu Alves Tatiane Neotti Felipe D´Almeida Costa Journal Article 2018 08 06 2018 09 17 Background: Extramedullary plasmacytomas occurs in about 20% of multiple myeloma (MM) recurrences. Extramedullary disease seems to respond poorly to thalidomide and has adverse prognostic implication. When disease recurs in the oral cavity with soft tissue infiltration, some authors defend upfront surgical excision prior to radiotherapy with the aim of achieving better local control. We describe herein such an atypical case of recurrence from MM, with complete local response after 2 cycles of chemotherapy. Unfortunately, disease progressed later on, and the patient died after 9 months post-recurrence. This emphasizes the prognostic impact of extramedullary disease manifestation in MM.