Academy of Medical Sciences of I.R. Iran Archives of Iranian Medicine 1029-2977 29 3 2026 03 01 Effectiveness of Noninvasive Brain Stimulation (NIBS) in Combination with Cognitive Analytic Psychotherapy (CAP); A Complex Cocaine Abuser Case 188 194 10.34172/aim.35307 EN Mohammad Khodayarifard https://orcid.org/0000-0002-2878-4324 Mahnoosh Kamranvand https://orcid.org/0000-0002-1326-0018 Reza Rostami https://orcid.org/0000-0001-9318-108X Journal Article 10.34172/aim.35307 2025 10 30 2026 02 21 Introduction: Drug addiction, a global problem affecting 275 million people, is a complex disorder characterized by compulsive substance use despite negative consequences. Neuroplasticity changes in the brain’s circuits, particularly those involving dopamine, play a crucial role in addiction. Non-invasive brain stimulation techniques, such as transcranial magnetic stimulation and transcranial direct current stimulation, show promise as adjunctive treatments for substance use disorders, including cocaine use disorder. Combining these brain stimulation therapies with psychological interventions may enhance treatment outcomes and reduce relapse rates. Case Report: In this study, a 38-year-old Iranian woman, diagnosed with cocaine use disorder, underwent a multi-faceted neuropsychological treatment program. Her husband also received psychological treatment but not biological treatment. After treatment, both the woman and her husband were able to completely stop using cocaine for more than three years. The study used various assessments, including self-report tests and brain mapping, to evaluate the effectiveness of the interventions. The woman showed a significant reduction in symptoms and improvement in mood regulation. Conclusion: This study highlights the effectiveness of a multifaceted approach to treating cocaine addiction, including neurological and psychological interventions. It suggests that non-invasive brain manipulation and Cognitive Analytic Psychotherapy (CAP) may be effective in treating complex cases. However, further research is needed to establish the efficacy of CAP for bipolar affective disorder. The study emphasizes the importance of considering biological, psychological, and social factors in treatment of substance use disorders.