Academy of Medical Sciences of I.R. Iran Archives of Iranian Medicine 1029-2977 28 3 2025 03 01 Retro-orbital Metastasis in Chromophobe Renal Cell Carcinoma: A Case Report and Review 171 173 10.34172/aim.31231 EN Tanju Kapagan https://orcid.org/0000-0001-9381-1934 Nilufer Bulut https://orcid.org/0000-0002-2406-1946 Mehmet Halıcı https://orcid.org/0000-0002-1778-6607 Gokmen Umut Erdem https://orcid.org/0000-0002-3375-9465 Journal Article 10.34172/aim.31231 2024 04 28 2024 11 02 Chromophobe renal cell carcinoma (ChRCC) is a rare subtype of renal cell carcinoma (RCC). We present a case of a 61-year-old male with ChRCC who exhibited unusual metastasis to the retro-orbital area, a site rarely affected by RCC. The patient experienced diplopia and proptosis, prompting treatment with sunitinib and palliative radiotherapy. Remarkably, rapid improvement in ocular symptoms was observed following radiotherapy. Despite this localized response, the patient’s overall condition deteriorated, highlighting the aggressive nature of ChRCC. This case underscores the importance of considering ChRCC in metastatic presentations and the potential efficacy of local palliative interventions.