Academy of Medical Sciences of I.R. Iran Archives of Iranian Medicine 1029-2977 27 7 2024 07 01 Causes of Colectomy in Patients with Ulcerative Colitis: Findings from an Iranian National Registry 350 356 10.34172/aim.28887 EN Zahra Momayez Sanat https://orcid.org/0000-0002-6143-4350 Homayoon Vahedi Reza Malekzadeh Amir Kasaeian Negar Mohammadi Ganjaroudi Alireza Sima Fariborz Mansour Ghanaei Mohammadreza Ghadir Hafez Tirgar Fakheri Siavosh Nasseri Moghaddam Sudabeh Alatab https://orcid.org/0000-0001-7592-4599 Anahita Sadeghi Amir Anushiravani Iradj Maleki Abbas Yazdanbod Hassan Vossoughinia Mohammadreza Seyyedmajidi Sayed Jalaleddin Naghshbandi Nadieh Baniasadi Baran Parhizkar Saied Matinkhah Shahsanam Gheibi Roya-sadat Hosseini Hemmat Abadi Seyedmohamad Valizadeh Toosi Journal Article 10.34172/aim.28887 2024 02 02 2024 06 05 Background: Ulcerative colitis (UC) is a form of inflammatory bowel disease (IBD) marked by rectal and colon inflammation, leading to relapsing symptoms. Its prevalence is increasing, particularly in developed nations, impacting patients’ health. While its exact cause remains unclear, genetic and environmental factors are implicated, elevating the risk of colorectal cancer (CRC). Colectomy, though declining, is still performed in select UC cases, necessitating further study. Methods: We analyzed data from the Iranian Registry of Crohn’s and Colitis (IRCC) to examine UC patients undergoing colectomy. We collected demographic and clinical data from 91 patients, focusing on dysplasia. Statistical analyses assessed dysplasia risk factors. Results: Patients with dysplasia were older at diagnosis and surgery compared to those without dysplasia. Age emerged as a significant risk factor for dysplasia in UC patients undergoing colectomy. No significant associations were found between dysplasia and other factors. Conclusion: Age plays a crucial role in dysplasia risk among UC patients undergoing colectomy. Older age at diagnosis and surgery may indicate a higher risk of dysplasia and CRC. Clinicians should consider age when managing UC patients and implementing screening protocols. Further research with larger samples is needed to confirm these findings.