Academy of Medical Sciences of I.R. Iran Archives of Iranian Medicine 1029-2977 25 9 2022 09 01 Syringocystadenoma Papilliferum in the External Ear Canal 658 660 10.34172/aim.2022.101 EN Sasa Jakovljevic https://orcid.org/0000-0002-5410-3078 Nenad Arsovic https://orcid.org/0000-0001-5277-5746 Novica Boricic https://orcid.org/0000-0002-7042-1033 Darko Laketic https://orcid.org/0000-0001-8228-8041 Zoran Dudvarski https://orcid.org/0000-0001-9534-2190 Journal Article 10.34172/aim.2022.101 2021 03 10 2021 11 06 Out of all benign tumors of the ceruminous glands, syringocystadenoma papilliferum is the rarest and represents only 2% of cases. It is an extremely rare benign tumor that originates from modified apocrine sweat glands. The aim of this paper was to present, according to our findings, the 18th case of syringocystadenoma papilliferum in the external auditory canal, with a detailed review of its clinical, radiological and histomorphological characteristics. A 59-year-old man reported to our clinic due to a 5×5 mm papillomatous growth at the entrance to the right external auditory canal. Histopathology indicated, after an excisional biopsy, that it was a syringocystadenoma papilliferum. The resection lines were free of tumor tissue, and the patient has no signs of tumor recurrence. Although rare, it should be considered as a differential diagnosis of lesions in this region. Complete excision is mandatory in order to avoid recurrence and potential malignant alteration.