Academy of Medical Sciences of I.R. Iran Archives of Iranian Medicine 1029-2977 23 8 2020 08 01 Fatal Infectious Epidemics in Iran in the Last Two Centuries; What Lessons Can We Learn from Preceding Outbreaks? A Brief Historical Review 578 581 10.34172/aim.2020.66 EN Mohammad Hossein Azizi Farzaneh Azizi Journal Article 10.34172/aim.2020.66 2020 06 01 2020 07 02 In the past two centuries, several fatal infectious outbreaks have arisen in Iran. Presented here is a brief historical account of four fatal epidemics including cholera, plague, Spanish influenza of 1918 and smallpox between1796 and 1979. The lessons from these outbreaks could be helpful for better combatting other deadly epidemics including the present-day disastrous COVID-19 pandemic.