Academy of Medical Sciences of I.R. Iran Archives of Iranian Medicine 1029-2977 21 1 2018 01 01 Primary Nonsecretory Plasma Cell Leukemia With Multiple Chromosomal Abnormalities: A Case Report 41 43 EN Satoshi Nakayama Tomohiro Oda Shinya Minabe Yukiharu Bamba Haruko Ukawa Rika Sato Masaki Kawabata Toshikatsu Horiuchi Junichi Watanabe Fumihiko Kimura Hideyuki Shimazaki Sho Ogata Kuniaki Nakanishi Journal Article 2017 03 03 2017 12 23 Primary nonsecretory plasma cell leukemia (PCL) is an extremely rare type of multiple myeloma. Here, we report a case of nonsecretory PCL with no previous history of multiple myeloma. The case exhibited extremely low levels of serum immunoglobulin and light chain, no detectable serum M-protein or free light chain restriction, no urine BJP, and no cytoplasmic light chain expression in flow cytometry. In fluorescence in situ hybridization, tumor cells exhibited fusion genes for IgH/BCL1 and IgH/cMyc, disappearance of the p53 signal, and a split signal for IgK(2p11), but no split signal for IgL (22q11). Therefore, we diagnosed primary nonsecretory PCL with multiple chromosomal abnormalities.