Academy of Medical Sciences of I.R. Iran Archives of Iranian Medicine 1029-2977 19 1 2016 01 01 Abrupt Development of Plasma Cell Leukemia in a Patient with Chronic Anemia under Follow-up 0 0 EN Mohamad Reza Farzaneh Ali Moradi Mohammad Reza Ravanbod Mohammad Daghbashi Journal Article Plasma cell leukemia (PCL) is a very rare and progressive hematologic malignancy with unpleasant prognosis, which present with monoclonal proliferation of plasma cells in peripheral blood. Here we report a 52-year-old female case of PCL which diagnosed by morphology and immunohistochemistery (IHC) study. IHC revealed CD20+/CD38+/CD138+/CD56-/kappa-/lambda+. We diagnose PCL on peripheral blood. IHC can be helpful for prognostic determination.