Academy of Medical Sciences of I.R. Iran Archives of Iranian Medicine 1029-2977 17 7 2014 07 01 Egyptian Concept of Rational Immune Modulation: Nature-Friendly Lifestyle for Taking Athero-Protective Phenotype 0 0 EN Mohaddeseh Behjati Journal Article A slightly lower rate of atherosclerosis in some tropical regions such as the Nile delta in Egypt, Saudi Arabia, Yemen and sub-Sahara Africa is associated with evidences of increased helminthic co-infection. Attempts to eradicate helminthic infections led to the shift of immune balance toward T helper 1 cells and their related cytokines. This shift is parallel with atherogenesis and its related complications. Atherosclerosis is a degenerative man-made disease which begins in early life. Thus, preventive strategies should begin at the same time. As an example to follow, living with old friends, adaption of a more nature-friendly lifestyle and "fine immune-modulation" plans from early childhood, like Egyptians, seems a good option. Finally, a proper intentional balance between T helper 1 and 2 cells should be defended and constructed environmentally in the manner compatible with modern hygiene using a soft application of old hygiene. This needs robust understanding of atheroprotective habits in regions with lower burden of atherosclerosis.