Academy of Medical Sciences of I.R. Iran Archives of Iranian Medicine 1029-2977 20 3 2017 03 01 Activation and Deactivation of 5-HT1 Receptor of Accumbens Shell Area does not Alter ACPA-induced Aversive Memory Deficit in Male Rat 0 0 EN Marzieh Keramati-nojedehsadat Shahrbanoo Oryan Mohammad Reza Zarrindast Vahab Babapour Journal Article BACKGROUND: Some studies have indicated a close relation between serotonergic and cannabinoidergic systems in several brain regions. Thus, the aim of current study is investigating the effect of 5-HT1 receptors of accumbens shell (Acb shell) on aversive memory deficit induced by ACPA (cannabinoid CB1 receptor agonist) using test-retest protocol of elevated plus-maze (EPM) in male Wistar rats. METHOD: Bilateral guide cannulae were implanted to allow microinjection of ACPA, CP94253 HCL (5-HT1 receptor agonist agonist) or GR127935 HCL (5-HT1 receptor antagonist). RESULTS: Post-test intra-Acb shell of ACPA (0.002 μg/rat), CP94253 (0.5 and 5 ng/rat) and GR127935 (5 ng/rat) increased the percentage of open-arms time (%OAT) in the EPM task compared to the control group, indicating aversive memory deficit. Moreover, concurrent microinjection of the subthreshold dose of CP94253 and GR127935 into Acb shell did not alter open-arms exploratory behavior induced by intra-Acb shell of ACPA on the retest day. CONCLUSION: Our data suggests that Acb shell 5-HT1 receptor does not affect aversive memory deficit induced by ACPA in the Acb shell.