Cristiano de Assis Pereira Hansen
1*, Jayr Schmidt Filho
2, Marina de Mattos Nascimento
2, Fábio Abreu Alves
3, Tatiane Neotti
4, Felipe D´Almeida Costa
51 Former Medical Resident in Clinical Oncology, A.C.Camargo Cancer Center, São Paulo, Brazil
2 Hematologist, A.C.Camargo Cancer Center, São Paulo, Brazil
3 Chief of Dental Surgery Department, A.C.Camargo Cancer Center, São Paulo, Brazil
4 Former Medical Resident in Pathology, A.C.Camargo Cancer Center, São Paulo, Brazil
5 Pathologist, A.C.Camargo Cancer Center, São Paulo, Brazil
Abstract
Background: Extramedullary plasmacytomas occurs in about 20% of multiple myeloma (MM) recurrences. Extramedullary disease
seems to respond poorly to thalidomide and has adverse prognostic implication. When disease recurs in the oral cavity with soft
tissue infiltration, some authors defend upfront surgical excision prior to radiotherapy with the aim of achieving better local control.
We describe herein such an atypical case of recurrence from MM, with complete local response after 2 cycles of chemotherapy.
Unfortunately, disease progressed later on, and the patient died after 9 months post-recurrence. This emphasizes the prognostic
impact of extramedullary disease manifestation in MM.