Arch Iran Med. 2019;22(7): 410-413.
PMID: 31679385
Scopus ID: 85071386416
  Abstract View: 2511
  PDF Download: 1476

Case Report

Granulomatosis with Polyangiitis Manifesting as Refractory Otitis Media and Mastoiditis

Huzaif Qaisar 1*, Mina Shenouda 1, Mohammed Shariff 1, Anmol Cheema 1, Xiaoyin Tang 1, Adam Kaplan 1*

1 Department of Medicine, Jersey Shore University Medical Center, Hackensack Meridian Health, Neptune, NJ 07753, USA
*Corresponding Authors: Email: huzaif.qaisar@hackensackmeridian.org; *Corresponding Author: Adam Kaplan, MD; Faculty, Internal Medicine Residency program, Department of Medicine, Jersey Shore University Medical Center, Core faculty and Assistant Professor of medicine, Hackensack-Meridian School of Medicine at Seton Hall, Neptune, NJ 07753, USA. Tel: 732-775-5500, Fax: 732-776-4052; Email: , Email: Adam.Kaplan@hackensackmeridian.orgAdam.Kaplan@HackensackMeridian.org


Granulomatosis with polyangiitis (GPA) is a rare rheumatologic disease characterized by small to medium vessel vasculitis and inflammation within multiple organ systems. Majority of cases involve both upper and lower respiratory tracts but other organs including brain, kidneys, joints and skin can also be involved. Patients who have recurrent otitis media and sinusitis often initially present to internists and then to ear nose and throat (ENT) physicians and may be treated with multiple courses of antibiotics without having proper workup for GPA. We present a middle-aged white male who exemplifies this unique presentation with new onset recurrent otitis media and mastoiditis, which did not respond to repeated courses of antibiotics requiring mastoidectomy and myringotomy tube placement. On chest x-ray, he was found to have multiple lung nodules that was followed by a computed tomography (CT) scan of his chest and CT guided biopsy which revealed granulomatous inflammation and necrosis, consistent with GPA. Autoimmune laboratory work-up was also suggestive of GPA. The patient had complete resolution of symptoms with steroid therapy. This case reinforces the concept of high index of suspicion of GPA for patients with recurrent and resistant otitis media or mastoiditis not responding to optimal duration and doses of antibiotics. Appropriate work-up for GPA may allow for earlier diagnosis of this devastating vasculitic disease which can help prevent multi-organ dysfunction.

Cite this article as: Qaisar H, Shenouda M, Shariff M, Cheema A, Tang X, Kaplan A. Granulomatosis with polyangiitis manifesting as refractory otitis media and mastoiditis. Arch Iran Med. 2019;22(7):410–413.
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Submitted: 03 Jul 2018
Accepted: 14 May 2019
ePublished: 01 Jul 2019
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