Abstract
Background: The probability of HIV transmission through contaminated blood and blood products is eye catching. 5%-10%
of blood products are contaminated with HIV. Therefore, it is essential to provide safe blood supply to prevent transmission of
infectious diseases. Current systematic review and meta-analysis was conducted to evaluate the weighted prevalence of HIV in
Iranian blood donors.
Methods: This study was reported according to PRISMA checklist for systematic reviews and meta- analysis. Required data were
collected by using key words such as “HIV”, “blood donation” OR “blood donors”, “epidemiology” OR “prevalence”, “blood
transfusion” and “Iran”, in international databases including PubMed, Scopus, Web of Science, Cochrane, Embase and national
databases including Magiran, IranMedex and Scientific Information Databank. Papers were searched until December 2017.
Cochran’s Q test and I2
index were used to assess the heterogeneity among studies.
Results: A total of 49 studies including 5403170 donors entered this meta-analysis. According to analysis, the prevalence of HIVpositive
patients among Iran blood donors was estimated 7.9/100000 (95% CI: 0.000052-0.000121%). The highest prevalence
was related to the central region of Iran (11.3/100,000 [95% CI:0.000063-0.0002%]) and Kermanshah province (49.2/100000
[95% CI:0.000273-0.000888%]) and the lowest prevalence was related to the eastern region (1/100000 [95% CI:0.000001-
0.000072%]) and Khorasan Razavi province (0.9/100000 [95% CI:0.000001-0.000139%].
Conclusion: The overall HIV prevalence in Iranian blood donors is low and satisfying. However, the high prevalence in some
regions and provinces should be reviewed more meticulously.