Su Jin Choi
1 
, Min Wook So
2 , Sunggun Lee
3, Seung Won Choi
1, Doo-Ho Lim
1* 1 Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea
2 Department of Internal Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, South Korea
3 Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea
Abstract
In contrast to experimental studies indicating the neuroprotective role of uric acid (UA), recent clinical studies have shown that increased UA is associated with a risk of acute hemorrhagic stroke. However, the association of UA with intraventricular hemorrhage (IVH) has not been adequately evaluated. In this study, we determined the relationship between UA and IVH in patients with intracerebral hemorrhage (ICH). We included 721 patients with ICH who were admitted to a tertiary hospital in South Korea. The patients were stratified into quartiles based on their UA levels. IVH decreased continuously across all quartiles of UA. After adjusting for confounding factors, the odds ratio (OR) for IVH was significantly lower in the fourth quartile compared with that in the first quartile (OR: 0.713; 95% CI: 0.546–0.934; P=0.045). In conclusion, UA is independently associated with IVH, suggesting its protective role against IVH in patients with ICH.