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Arch Iran Med. 2024;27(11): 598-605.
doi: 10.34172/aim.30020
PMID: 39534993
PMCID: PMC11558611
Scopus ID: 85209125760
  Abstract View: 453
  PDF Download: 421

Original Article

Prevalence and Correlates of Probable Nonalcoholic Steatohepatitis (NASH) in Pars Cohort Study

Amin Nakhostin-Ansari 1 ORCID logo, Iman Menbari Oskouie 2, Reyhaneh Aghajani 2, Mohammad Mehdi Khadembashiri 1, Mohammad Ahmadi 2, Abdollah Gandomkar 3, Fatemeh Malekzadeh 4, Hossein Poustchi 4, Mohammad Reza Fattahi 5, Amir Anushiravani 4, Reza Malekzadeh 4* ORCID logo

1 Neuromusculoskeletal Research Center, Iran University of Medical Sciences, Tehran, Iran
2 Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
3 Non-Communicable Disease Research Center, Shiraz University of medical Sciences, Shiraz, Iran
4 Liver and Pancreatobiliary Diseases Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Teheran, Iran
5 Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
*Corresponding Author: Reza Malekzadeh, Email: malek@tums.ac.ir

Abstract

Background: Studies on the prevalence of nonalcoholic steatohepatitis (NASH) and the factors associated with its high prevalence among Iranian people are limited. This study evaluated the prevalence of NASH and its associated factors among Iranian adults using Pars Cohort Study (PCS) data.

Methods: This cross-sectional study was conducted based on PCS, which includes 40-75-year-old adults from the Valashahr area. NASH was defined as alanine aminotransferase (ALT) higher than 40 U/L without evidence of hepatitis B or C infections. The prevalence of NASH and its associations with basic and demographic characteristics, socioeconomic characteristics, medical history, gastrointestinal symptoms, and laboratory tests were evaluated.

Results: Overall, 8734 patients, including 3917 men (44.8%), were enrolled in this study. The mean age of participants was 52.62 years (SD=9.68), and 605 individuals had NASH (6.9%). In the regression analysis, in contrast to female gender (OR=0.31, 95% CI=0.249‒0.386, P<0.001) and age (OR=0.951, 95% CI=0.941‒0.962, P<0.001), history of heart disease (OR=1.499, 95% CI=1.146‒1.962, P=0.003), history of diabetes (OR=1.523, 95% CI=1.162‒1.995, P=0.002), hypertension (OR=1.241, 95% CI=1.023‒1.506, P=0.029), being overweight or obese (OR=2.192, 95% CI=1.755‒2.737, P<0.001), being in the richest or second richest wealth index quantiles (OR=1.315, 95% CI=1.107‒1.156, P=0.002), and increased waist circumference (OR=1.409, 95% CI=1.107‒1.793, P<0.005) were independently associated with a higher risk of having NASH.

Conclusion: In this study, we determined the prevalence of NASH and found male gender, younger age, history of heart disease, history of diabetes, hypertension, socioeconomic status, and obesity as possible factors associated with a higher risk of NASH among Iranians.


Cite this article as: Nakhostin-Ansari A, Menbari Oskouie I, Aghajani R, Khadembashiri MM, Ahmadi M, et al. Prevalence and correlates of probable nonalcoholic steatohepatitis (NASH) in Pars Cohort Study. Arch Iran Med. 2024;27(11):598-605. doi: 10.34172/aim.30020
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