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Arch Iran Med. 2024;27(8): 456-464.
doi: 10.34172/aim.28772
PMID: 39306718
PMCID: PMC11416695
Scopus ID: 85201877382
  Abstract View: 395
  PDF Download: 334

Original Article

Potentiation of Imipramine-Induced Anti-hyperalgesic and Anti-Nociceptive Effects by Citicoline in the Sciatic Nerve Ligated Mice

Negar Raissi-Dehkordi 1 ORCID logo, Nastaran Raissi-Dehkordi 1, Bardia Hajikarimloo 1, Fatemeh Khakpai 2,3, Moammad-Reza Zarrindast 4,5,6* ORCID logo

1 School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Department of Physiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
3 Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
4 Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
5 Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran
6 Institute for Cognitive Science Studies (ICSS), Tehran, Iran
*Corresponding Author: Mohammad-Reza Zarrindast, Email: zarinmr@ams.ac.ir

Abstract

Background: Peripheral neuropathic pain is a result of damage/illness of the peripheral nerves. The mechanisms caused by its pathophysiology are not completely understood.

Methods: Imipramine is a tricyclic antidepressant that is sometimes used to treat neuropathic pain. Moreover, citicoline is considered a novel adjuvant for painful disorders such as neuropathic pain. So, a possible interaction between imipramine and citicoline on pain behavior was examined in nerve-ligated mice using tail-flick and hot plate tests.

Results: The results indicated that induction of neuropathic pain by sciatic nerve ligation caused hyperalgesia in nerve-ligated mice. On the other hand, intraperitoneal (i.p.) administration of citicoline (50, 75, and 100 mg/kg), and imipramine (2.5 and 5 mg/kg) induced anti-hyperalgesic and anti-nociceptive effects in nerve-ligated mice. Furthermore, citicoline potentiated the anti-hyperalgesic and anti-nociceptive effects of imipramine when they were co-administrated in nerve-ligated mice. Interestingly, there was an additive effect between imipramine and citicoline upon induction of anti-hyperalgesic and anti-nociceptive effects in nerve-ligated mice.

Conclusion: Therefore, it can be concluded that citicoline (as an adjuvant substance) enhanced the efficacy of imipramine for the modulation of pain behavior in nerve-ligated mice


Cite this article as: Raissi Dehkordi N, Raissi-Dehkordi N, Hajikarimloo B, Khakpai F, Zarrindast MR. Potentiation of imipramineinduced anti-hyperalgesic and anti-nociceptive effects by citicoline in the sciatic nerve ligated mice. Arch Iran Med. 2024;27(8):456-464. doi: 10.34172/aim.28772
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Submitted: 30 Dec 2023
Accepted: 12 Jun 2024
ePublished: 01 Aug 2024
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