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Arch Iran Med. 2024;27(8): 421-426.
doi: 10.34172/aim.28564
PMID: 39306713
PMCID: PMC11416692
Scopus ID: 85201862950
  Abstract View: 540
  PDF Download: 313

Original Article

Comparison of Factors Influencing Gestational Outcomes in Healthy Versus Hypothyroid Women from Karachi, Pakistan

Zareen Kiran 1* ORCID logo, Adeel Khoja 1, Imdad Ali Khushk 2, Aisha Sheikh 1, Najmul Islam 1

1 Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan
2 Health Services Academy, Islamabad, Pakistan
*Corresponding Author: Zareen Kiran, Email: zareen.kiran@aku.edu, Email: drzareenkiran@gmail.com

Abstract

Background: Gestational outcomes are known to be negatively correlated with hypothyroidism. This study was designed to compare the maternal factors affecting gestational outcomes in women with and without hypothyroidism.

Methods: This retrospective analysis was carried out in a tertiary hospital in Karachi, Pakistan, between 2008 and 2016. A standardized form was used to collect information on the age of the mother, gestational duration at the prenatal appointment, gestational diabetes mellitus (GDM), hypertension, and past records of miscarriages in hypothyroid and healthy pregnant women. Gestational outcomes were recorded as live birth or pregnancy loss. Statistical analysis was performed to examine overt versus sub-clinical hypothyroidism and among those diagnosed before versus during gestation.

Results: A collective of 708 women were enlisted in the hypothyroid pregnant group and 759 were recruited in healthy controls. Pregnancy loss was 9.9% (n=70) in hypothyroid women, whereas it was 14.3% (n=108) in the control group. The age of the mother, gestational duration at the prenatal appointment, and past records of miscarriages were discovered to be related to a higher chance of pregnancy loss in a multivariable analysis, but GDM (OR 0.04, CI 0.06-0.32, P=0.002) and hypothyroidism (OR 0.62, CI 0.43-0.89, P=0.01) exhibited a protective effect.

Conclusion: This study found the age of the mother, gestational duration at a prenatal appointment, and past records of miscarriages to be associated with negative outcomes in hypothyroidism. These factors remained significant in overt as well as subclinical hypothyroid women.


Cite this article as: Kiran Z, Khoja A, Khushk IA, Sheikh A, Islam N. Comparison of factors influencing gestational outcomes in healthy versus hypothyroid women from Karachi, Pakistan. Arch Iran Med. 2024;27(8):421-426. doi: 10.34172/aim.28564
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Submitted: 25 Nov 2023
Accepted: 26 Jun 2024
ePublished: 01 Aug 2024
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