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Arch Iran Med. 2023;26(5): 275-278.
doi: 10.34172/aim.2023.42
PMID: 38301091
PMCID: PMC10685867
Scopus ID: 85171475733
  Abstract View: 962
  PDF Download: 672

Case Report

Celecoxib in Treatment of Postpartum Depression: A Case Report

Sophia Esalatmanesh 1,2 ORCID logo, Ladan Kashani 1, Shahin Akhondzadeh 2* ORCID logo

1 Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
2 Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran
*Corresponding Author: Shahin Akhondzadeh, Email: s.akhond@neda.net

Abstract

Postpartum depression (PPD) impairs mother-infant interaction and has negative effects on the child’s emotional, behavioral, and cognitive skills. There is considerable evidence to suggest that inflammation plays a role in the pathogenesis of depression. Controlled trials indicate that celecoxib has antidepressant effects in patients with major depressive disorder. A 34-year-old woman with mild to moderate PPD received a celecoxib capsule twice a day. This treatment has not been reported in previous studies and is novel in clinical practice. The patient was assessed using the Hamilton Depression Rating Scale (HDRS). Moreover, levels of brain-derived neurotrophic factor (BDNF) and inflammatory cytokines were measured at baseline and at the end of celecoxib therapy. This case suggests that celecoxib can improve depressive symptoms in patients with mild to moderate PPD. No adverse effects occurred during follow-up.

Cite this article as: Esalatmanesh S, Kahani L, Akhondzadeh S. Celecoxib in treatment of postpartum depression: a case report. Arch Iran Med. 2023;26(5):275-278. doi: 10.34172/aim.2023.42
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Submitted: 12 Apr 2023
Accepted: 23 Apr 2023
ePublished: 01 May 2023
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