Anti-N-methyl D-aspartate Receptor Encephalitis Following ChAdOx1 nCoV-19 Vaccination: A Case Report

Zahra Liyaghatdar; Amirhosein Rahimkhani; Amin Liaghatdar

doi:10.34172/aim.2023.87

Arch Iran Med. 2023;26(10): 600-603.
doi: 10.34172/aim.2023.87

PMID: 38310417
PMCID: PMC10862091
Scopus ID: 85184109862

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COVID-19

Case Report

Anti-N-methyl D-aspartate Receptor Encephalitis Following ChAdOx1 nCoV-19 Vaccination: A Case Report

Zahra Liyaghatdar ¹ , Amirhosein Rahimkhani ², Amin Liaghatdar ²^*

¹ Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
² Faculty of Medical Sciences, Zahedan University of Medical Sciences, Zahedan, Iran

*Corresponding Author: Amin Liaghatdar, Emails: Amin_Liaghatdar@yahoo.com; , Email: Amin.lg@zaums.ac.ir

Abstract

As of December 2020, millions of people have been immunized using vaccines against SARS-CoV-2. A wide range of neurological adverse effects of SARS-CoV-2 vaccines have been reported so far. Here, we report a 23-year-old male who experienced psychiatric symptoms, loss of consciousness, language disintegration, and incontinency that happened 10 days after the first dosage of the COVID-19 AstraZeneca vaccine. Anti-NMDAR Encephalitis was diagnosed based on the results of the autoimmune panel. The patient responded to intravenous dexamethasone very well and experienced no other complications in 6 months of follow-up. Scientific reports of neurological side effects such as anti-NMDAR encephalitis after vaccination are necessary to optimize the safety and effectiveness of SARS-CoV-2 vaccines.

Keywords: Anti-NMDAR encephalitis, Autoimmune encephalitis, Case report, ChAdOx1 nCoV-19 vaccine

Cite this article as: Liyaghatdar Z, Rahimkhani A, Liaghatdar A. Anti-N-methyl D-aspartate receptor encephalitis following ChAdOx1 nCoV-19 vaccination: a case report. Arch Iran Med. 2023;26(10):600-603. doi: 10.34172/aim.2023.8