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Arch Iran Med. 2024;27(1): 44-47.
doi: 10.34172/aim.2024.07
PMID: 38431960
PMCID: PMC10915934
Scopus ID: 85186200348
  Abstract View: 369
  PDF Download: 337

Case Report

Primary Hepatic Neuroblastoma in a 5.5-Month-Old Boy: A Case Report

Farzad Kompani 1 ORCID logo, Alieh Safari Sharari 1, Elmira Haji Esmaeil Memar 2* ORCID logo, Mahya Ghahremanloo 2 ORCID logo

1 Division of Hematology and Oncology, Children’s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Pediatrics, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
*Corresponding Author: Elmira Haji Esmaeil Memar; Email: dr.elmira.memar@gmail.com, Email: dr.elmira.memar@gmail.com

Abstract

The most frequent type of extracranial solid tumor in pediatric cases is neuroblastoma (NB), almost always arising in tissues with sympathetic innervation with only a few reported cases arising in other organs. NBs with hepatic involvement are typically metastatic lesions as primary hepatic NBs are extremely rare. This study presents a 5.5-month-old boy with primary hepatic NB. This case study describes a male 5.5-month-old preterm infant who presented with overt hepatomegaly. Laboratory tests showed an abnormally high level of alpha-fetoprotein. A sonography-guided liver needle biopsy was performed, so histopathological examination suggested the diagnosis of a small round-cell tumor. Immunohistochemical staining demonstrated evidence of neuronal differentiation in the tumor. The sum of these findings was in favor of the diagnosis of NB. Bone marrow aspiration and biopsy were normal. The full-body computed tomography scan revealed a large intrahepatic mass measuring 82×70×74 mm with mild peripheral enhancement. A metaiodobenzylguanidine (MIBG) scintiscan confirmed a huge round MIBG-avid hepatic lesion without other remarkable lesions at other sites in the body. Chemotherapy treatment was started for the patient, and after 4 sessions of chemotherapy, an ultrasound showed that the mass size had decreased to 55×36 mm. This report describes the first primary hepatic NB in a pediatric patient with detailed clinicopathological details. Primary hepatic NB is extremely rare. It is important to consider neuroendocrine tumors as a possibility when faced with a single hepatic tumor that has a similar histological appearance.

Cite this article as: Kompani F, Safari Sharari A, Haji Esmaeil Memar E, Ghahremanloo M. Primary hepatic neuroblastoma in a 5.5-month-old boy: a case report. Arch Iran Med. 2024;27(1):44-47. doi: 10.34172/aim.2024.07
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Submitted: 22 Jan 2023
Accepted: 03 Jul 2023
ePublished: 01 Jan 2024
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