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Arch Iran Med. 2023;26(1): 43-49.
doi: 10.34172/aim.2023.07
PMID: 37543921
PMCID: PMC10685811
Scopus ID: 85162136718
  Abstract View: 1052
  PDF Download: 563

COVID-19

Original Article

Maternal and Neonatal Outcomes of COVID-19 Infection in Pregnancy

Maryam Vizheh 1,2 ORCID logo, Maryam Allahdadian 3* ORCID logo, Hatav Ghasemi-Tehrani 4*, Salut Muhidin 5, Maryam Hashemi 6, Maryam Dehghan 6

1 Australian Institute of Health Innovation (AIHI), Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, 2109, Australia
2 Department of Reproductive Health and Midwifery, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran
3 Department of Midwifery, Nursing & Midwifery Faculty, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
4 Fertility Department, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran
5 Department of Management, Macquarie Business School, Macquarie University, New South Wales, 2109, Australia
6 Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
*Corresponding Authors: Maryam Allahdadian, Email: maryamallahdadian@yahoo.com; Hatav Ghasemi-Tehrani, Email: hatav.tehrani2014@gmail.com

Abstract

Background: Limited data is available on the full spectrum of maternal COVID-19 infection in terms of pregnancy outcomes. The present study aimed to compare the maternal and neonatal outcomes of COVID-19 in infected and non-infected pregnant women.

Methods: A dual-site retrospective cohort study was conducted in two tertiary hospitals in Isfahan, Iran. The sample included 104 infected and 210 non-infected hospitalized pregnant women. Odds ratios (OR) were estimated using multivariate logistic regression.

Results: There were significant differences between COVID-19-infected and non-infected pregnant women regarding preterm labor (PTL) (odds ratio [OR]: 11.34, 95% confidence interval [CI]: 1.19–48.54, P=0.035); hospitalization days (OR: 7.21, 95% CI: 4.05–12.85, P≤0.001); cesarean section (CS) (OR: 4.76, 95% CI: 1.78–12.45, P=0.002); neonatal admission to neonatal intensive care unit (NICU) (OR: 1.28, 95% CI: 1.12–1.67, P=0.004); and neonatal respiratory distress (OR: 2.37, 95% CI: 1.02– 5.47, P=0.044). No significant association was found between COVID-19 infection and abortion (OR: 0.06, 95% CI: 0.01–1.45, P=0.084); stillbirth (OR: 1.84, 95% CI: 0.05–39.68, P=0.743); Apgar score (1 minute) (OR: 0.91, 95% CI: 0.74–1.13, P=0.382); Apgar score (5 minutes) (OR: 0.97, 95% CI: 0.81–1.18, P=0.765); and low birth weight (LBW) (OR: 4.76, 95% CI: 1.78–12.45, P=0.002).

Conclusion: PTL, CS, neonatal admission in NICU, neonatal respiratory distress, and hospitalization days were significantly higher in pregnant women with COVID-19 compared to those without infection.


Cite this article as: Vizheh M, Allahdadian M, Ghasemi-Tehrani H, Muhidin S, Hashemi M, Dehghan M. Maternal and neonatal outcomes of COVID-19 infection in pregnancy. Arch Iran Med. 2023;26(1):43-49. doi: 10.34172/aim.2023.07
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Submitted: 05 Sep 2021
Revision: 08 Mar 2022
Accepted: 13 Mar 2022
ePublished: 01 Jan 2023
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