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Arch Iran Med. 2018;21(4): 170-179.
PMID: 29693408
Scopus ID: 85062891097
  Abstract View: 2583
  PDF Download: 1404

Review

Calpains: Diverse Functions but Enigmatic

Masoumeh Hosseini 1, Hossein Najmabadi 1, Kimia Kahrizi 1*

1 Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
*Corresponding Author: *Corresponding Authors: Kimia Kahrizi MD, Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. Email: kahrizi@ yahoo.com; Hossein Najmabadi, Email: hnajm12@yahoo.com, Email:

Abstract

Calpains are a group of non-lysosomal Ca2+-dependent cysteine proteases with numerous substrates. Calpains have been identified in almost all eukaryotes and bacteria but not in archaebacteria. In the human genome, this group of enzymes has 15 isoforms and is present ubiquitously and demonstrates tissue-specific patterns of expression. Calpains are involved in different physiological and pathological processes such as cell proliferation, migration, invasion, apoptosis and signal transduction and their roles in various disorders have been reported. In this review, functions of calpains, their substrates, their mechanism of regulation and their involvement in diseases have been summarized.

Cite this article as: Hosseini M, Najmabadi H, Kahrizi K. Calpains: diverse functions but enigmatic. Arch Iran Med. 2018;21(4):170– 179.
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Submitted: 23 Oct 2017
Accepted: 10 Jan 2018
ePublished: 01 Apr 2016
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