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Arch Iran Med. 2021;24(9): 678-683.
doi: 10.34172/aim.2021.97

Scopus ID: 85117421183
  Abstract View: 2088
  PDF Download: 1124

Original Article

Epidemiological Study of Various HPV Strains in Cervical Fluid Samples in South-Eastern Iran, 2018–2020

Reza Bahramabadi 1 ORCID logo, Zahra Honarvar 2, Maryam Iranpour 1, Mohammad Kazemi Arababadi 3, Tania Dehesh 4, Bahram Dabiri 1,5, Abbas Mortezaeizadeh Anari 1, Sahar Amirpour Rostami 6, Mohammad Salajegheh 1, Shahriar Dabiri 1* ORCID logo

1 Pathology and Stem Cell Research Center, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
2 Department of Obstetrics and Gynecology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
3 Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, and Department of Laboratory Sciences, Faculty of Paramedicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
4 Department of Biostatistics and Epidemiology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
5 Department of Pathology, Resident NYU Langone Health, Mineloa, NY, USA
6 Pharmaceutics Research Centre, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
*Corresponding Author: *Corresponding Author: Shahriar Dabiri, MD, FIAC; Pathology and Stem Cell Research Center, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman 7616913555, Iran. Tel: +98-34-33257671; Fax: +98-34-33257112; Email: , Email: dabiri12@yahoo.com

Abstract

Background: Uterine cervical malignancy is one of the commonly detected malignancies related to the human papillomavirus (HPV) and is increasing incidentally in developing countries. Therefore, the use of an efficient diagnostic method is required as an effectual step for cervical cancer prevention and treatment. The purpose of the study was to diagnose various types of HPV in the cervical cytology specimens in the South-East of Iran.

Methods: This cross-sectional study was performed on 1079 cervical fluid cytology specimens referred for two years, between 2018-2020. Polymerase chain reaction (PCR) and hybridization (INNO-LiPA HPV Genotyping EXTRA II assay) were used to determine HPV DNA and their genotypes, respectively.

Results: HPV was positive in 37.7% (407 of 1079) patients with a mean age of 34.62 ± 8.82. Among positive cases, 252 (62%) had only one HPV genotype and 155 (38.05%) had multiplex HPV genotypes, which included 94 (60.7%), 38 (24.6%), 18 (11.6%) and 5 (3.2%) cases with two, three, four and five or more genotypes, respectively. The samples with multiple strains revealed 31 HPV genotypes with the four most prevalent being HPV6 (14.7%), HPV16 (10.9%), HPV53 (9.6%) and HPV51 (5.9%).

Conclusion: HPV infection is the main health challenge for women that requires improved health service programs and appropriate epidemic vaccination.



Cite this article as: Bahramabadi R, Honarvar Z, Iranpour M, Kazemi Arababadi M, Dehesh T, Dabiri B, et al. Epidemiological study of various hpv strains in cervical fluid samples in south-eastern iran, 2018–2020. Arch Iran Med. 2021;24(9):678-683. doi: 10.34172/aim.2021.97
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Submitted: 07 Nov 2020
Revision: 10 Jan 2021
Accepted: 13 Jan 2021
ePublished: 01 Sep 2021
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