Satoshi Nakayama
1*, Tomohiro Oda
1, Shinya Minabe
1, Yukiharu Bamba
1,2, Haruko Ukawa
1, Rika Sato
1, Masaki Kawabata
1, Toshikatsu Horiuchi
3, Junichi Watanabe
3, Fumihiko Kimura
3, Hideyuki Shimazaki
1, Sho Ogata
1, Kuniaki Nakanishi
11 Department of Laboratory Medicine, National Defense Medical College Hospital, Tokorozawa, Japan
2 Department of Pathology and Cytology, PCL Japan, Inc., Kawagoe, Japan
3 Division of Hematology, Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan
*Corresponding Author: Corresponding Author: Satoshi Nakayama, MT; Department of Laboratory Medicine, National Defense Medical College Hospital, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. , Email:
nakayama@ndmc.ac.jp
Abstract
Primary nonsecretory plasma cell leukemia (PCL) is an extremely rare type of multiple myeloma. Here, we report a case of nonsecretory PCL with no previous history of multiple myeloma. The case exhibited extremely low levels of serum immunoglobulin and light chain, no detectable serum M-protein or free light chain restriction, no urine BJP, and no cytoplasmic light chain expression in flow cytometry. In fluorescence in situ hybridization, tumor cells exhibited fusion genes for IgH/BCL1 and IgH/cMyc, disappearance of the p53 signal, and a split signal for IgK(2p11), but no split signal for IgL (22q11). Therefore, we diagnosed primary nonsecretory PCL with multiple chromosomal abnormalities.