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Arch Iran Med. 2017;20(12): 734-739.
PMID: 29664312
Scopus ID: 85044277226
  Abstract View: 2950
  PDF Download: 1583

Original Article

Adverse Cardiometabolic Effect in Bilateral/Unilateral Oophorectomy Versus Natural Menopause: Results of Over a Decade Follow-up Among Iranian Women

Maryam Farahmand 1, Fahimeh Ramezani Tehrani 1*, Mahnaz Bahri Khomami 1, Fereidoun Azizi 2

1 Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
*Corresponding Author: Corresponding Author: Fahimeh Ramezani Tehrani, MD; Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, No 24, Parvane Street, Yaman Street, Velenjak, P. O. Box: 19395-4763, Tehran, Iran. Tel: +98-21-22432500, Fax: +9821-22416264, Email: ramezani@endocrine.ac.ir

Abstract

Background: To compare metabolic changes in 3 groups of postmenopausal women: those who had undergone bilateral salpingooophorectomy + hysterectomy (BSO + H), those with hysterectomy ± unilateral salpingo-oophorectomy (H ± USO), and those who reached natural menopause during follow-up.

Methods: This longitudinal study was performed on 543 female participants of the Tehran Lipid and Glucose Study (TLGS) who experienced surgical menopause (BSO + H or H ± USO) or natural menopause over a 12-year period. During the follow-up period, changes in metabolic and biochemical profiles were compared between surgically and naturally menopausal women (NMW). In all groups, data was collected using questionnaires twice, at baseline and again after 3 years.

Results: Considering the women with natural menopause as the reference group, the odds ratio of metabolic syndrome was 5.0 in the surgically menopause due to BSO + H. Mean fasting blood glucose was also significantly higher in the H ± USO group, compared to the naturally menopausal, after adjustment for confounding variables.

Conclusion: The incidence of metabolic syndrome in the BSO + H group and that of fasting blood glucose in the H ± USO group were higher than NMW.


Cite this article as: Farahmand M, Ramezani Tehrani F, Bahri Khomami M, Azizi F. Adverse cardiometabolic effect in bilateral/ unilateral oophorectomy versus natural menopause: results of over a decade follow-up among Iranian women. Arch Iran Med. 2017;20(12):734–739.
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Submitted: 03 Oct 2016
Accepted: 18 Oct 2017
ePublished: 01 Dec 2017
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