Sedigheh Tahmasebi
1, Ali Mosa Jafar Almayali
2, Peyman Arasteh
1, Majid Akrami
1*, Vahid Zangouri
1,3, Payam Arasteh
1,4, Seyed Morteza Hosseini
1, Aida Salehi Nobandegani
1, Azam Asgari
1, Erfan Sadeghi
5,6, Leila Zahiri
7, Abdolrasoul Talei
11 MBreast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2 Department of Surgery, Karbala University of Medical Sciences, Karbala, Iraq
3 Surgical Oncology Division, General Surgery Department, Shiraz University of Medical Sciences, Shiraz, Iran
4 Department of Foreign Languages and Linguistics, Shiraz University, Shiraz, Fars, Iran
5 Non-communicable Disease Research Center, Fasa University of Medical Sciences, Fasa, Iran
6 Department of Biostatistics and Epidemiology, Faculty of Health, Isfahan University of Medical Sciences, Isfahan, Iran
7 Department of Internal Medicine, Shiraz University of Medical Science, Shiraz, Iran
*Corresponding Author: *Corresponding Author: Majid Akrami, MD; Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Tel: +98-917-3116280; Email: , Email:
shirazoncosurgery@gmail.com
Abstract
Background: The outcome of patients with triple-negative breast cancer (TNBC) is highly dependent on demographic factors and ethnicity. We aimed to evaluate the clinicopathological determinants of prognosis among women with TNBC using data from one of the largest breast cancer (BC) registries.
Methods: A total of 6145 patients with BC from our referral center were evaluated from 1995 to 2018, among whom 523 had TNBC. The baseline, menstrual and reproductive, treatment and pathology related characteristics were evaluated.
Results: Among TNBC patients, the rate of stage 3 and 4 BC (29.9% vs. 14.4% and 7.8% vs. 0% for stage 3 and 4, respectively; P<0.001), invasive ductal carcinoma (90.7% vs. 75.6%; P=0.004), nodal involvement (46.7% vs. 33.4%; P=0.026), mastectomy (57.3% vs. 37.8%; P=0.001) and axillary node dissection (76.7% vs. 59.8%; P=0.019) was significantly higher in the group that developed recurrence.
Disease-free-survival was 80.6% (157.76 ± 9.48 months) and overall-survival was 90.1% (182.73 ± 3.28 months). For death, stage 3 BC (compared to stages 0 and 1 as base) showed a higher risk of earlier death (adjusted HR: 4.191, 95% CI=1.392-12.621; P=0.011). For recurrence, stage 3 BC (adjusted HR: 1.044, 95% CI=1.209-6.673; P=0.017) (compared to stages 0 and 1 as base) showed significantly higher risk for developing earlier recurrence. Moreover, those who had invasive ductal carcinoma (compared to other types of BCs) had a higher risk for developing earlier recurrence (adjusted HR: 3.307, 95% CI=1.191-0.724; P=0.012).
Conclusion: BC stage plays a significant role in both earlier recurrence and earlier mortality among patients with TNBC.