Arch Iran Med. 2012;15(7): 0.
PMID: 22724879
Scopus ID: 84865623977
  Abstract View: 4746
  PDF Download: 4112

Original Article

Intra-articular Injection of Autologous Mesenchymal Stem Cells in Six Patients with Knee Osteoarthritis

Mohsen Emadedin, Naser Aghdami, Leila Taghiyar, Roghayeh Fazeli, Reza Moghadasali, Shahrbanoo Jahangir, Reza Farjad, Mohamadreza Baghaban Eslaminejad*
*Corresponding Author: Email: eslami@royaninstitute.org


BACKGROUND: Osteoarthritis (OA) is a progressive disorder of the joints caused by gradual loss of articular cartilage, which naturally possesses a limited regenerative capacity. In the present study, the potential of intra-articular injection of mesenchymal stem cells (MSCs) has been evaluated in six osteoarthritic patients.
METHODS: Six female volunteers, average age of 54.56 years, with radiologic evidence of knee OA that required joint replacement surgery were selected for this study. About 50 ml bone marrow was aspirated from each patient and taken to the cell laboratory, where MSCs were isolated and characterized in terms of some surface markers. About 20-24×106 passaged-2 cells were prepared and tested for microbial contamination prior to intra-articular injection.
RESULTS: During a one-year follow-up period, we found no local or systemic adverse events. All patients were partly satisfied with the results of the study. Pain, functional status of the knee, and walking distance tended to be improved up to six months post-injection, after which pain appeared to be slightly increased and patients’ walking abilities slightly decreased. Comparison of magnetic resonance images (MRI) at baseline and six months post-stem cell injection displayed an increase in cartilage thickness, extension of the repair tissue over the subchondral bone and a considerable decrease in the size of edematous subchondral patches in three out of six patients.
CONCLUSION: The results indicated satisfactory effects of intra-articular injection of MSCs in patients with knee OA.

First Name
Last Name
Email Address
Security code

Abstract View: 4747

Your browser does not support the canvas element.

PDF Download: 4112

Your browser does not support the canvas element.

ePublished: 01 Jul 2012
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)