Arch Iran Med. 2019;22(9): 527-530.
PMID: 31679375
Scopus ID: 85074389815
  Abstract View: 1545
  PDF Download: 845

Case Report

Pure Androgen-Secreting Adrenocortical Carcinoma Presenting with Hypoglycemia

Fariba Karimi 1* ORCID logo, Amirreza Dehghanian 2, Mohammadjavad Fallahi 3, Behnam Dalfardi 3

1 Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2 Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3 Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
*Corresponding Author: Email: karimif2002@yahoo.com


Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy. Most patients present with steroid hormone excess or abdominal mass effect. Pure androgen-secreting ACCs are rare, while hypoglycemia is an unusual presentation of this malignancy. We present a 26-year-old woman with hypoglycemia and history of adrenalectomy due to a large adrenal mass which was diagnosed as nonfunctional adrenal adenoma. She was admitted in our hospital 10 days after her fetal loss with repeated episodes of severe hypoglycemia. She had a high serum dehydroepiandrosterone sulfate (DHEA-S) and her hypoglycemia was associated with low insulin and C-peptide levels. Imaging revealed liver metastasis and immunohistochemical studies of the biopsied lesions confirmed the diagnosis of ACC.

Cite this article as: Karimi F, Dehghanian A, Fallahi M, Dalfardi B. Pure androgen-secreting adrenocortical carcinoma presenting with hypoglycemia. Arch Iran Med. 2019;22(9):527–530.
First Name
Last Name
Email Address
Security code

Abstract View: 1546

Your browser does not support the canvas element.

PDF Download: 845

Your browser does not support the canvas element.

Submitted: 23 Dec 2018
Accepted: 04 Feb 2019
ePublished: 01 Sep 2019
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)