Arch Iran Med. 2022;25(7): 450-455.
doi: 10.34172/aim.2022.74

Scopus ID: 85139341493
  Abstract View: 543
  PDF Download: 481

Review Article

The Impact of COVID-19 on Cancer Recurrence: A Narrative Review

Ahmad R Mafi 1* ORCID logo, Ali Ghanbari Motlagh 1 ORCID logo, Payam Azadeh 1 ORCID logo

1 Radiation Oncology Department, Imam Hossein Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
*Corresponding Author: Corresponding Author: Ahmad Reza Mafi, MD, MSc; Radiation Oncology Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Imam Hossein Hospital, Tehran, Iran. Email: , Email: ahmadrmafi@yahoo.com


Severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) continues to be a worldwide healthcare problem. While our knowledge of the interaction of cancer and its management with COVID-19 mortality is gradually evolving, there are still many unanswered questions regarding the impact of COVID-19 on cancer and its prognosis. Several factors activated during COVID-19 have been implicated in tumorigenesis and the development of metastasis. Inflammation, hypoxia, reduced levels of angiotensin converting enzyme 2, elevated levels of Interleukin 6 and some other cytokines that are hallmarks of COVID-19 are capable of inducing tumor relapse and metastasis. On the other hand, there are reports that COVID-19 has been associated with cancer cure. Understanding the interaction between COVID-19 and tumor cells is essential for evaluating the potential long-term risks of COVID-19 in cancer patients, and for scheduling necessary preventive and therapeutic interventions. In this review, we briefly overview the potential impacts that COVID-19 might have on tumorigenesis and cancer relapse, as well as the role that COVID-19 might play in cancer remission and cure.

Cite this article as: Mafi AR, Ghanbari Motlagh A, Azadeh P. The impact of Covid-19 on cancer recurrence: a narrative review. Arch Iran Med. 2022;25(7):450-455. doi: 10.34172/aim.2022.74
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Submitted: 30 Aug 2021
Revision: 01 Jan 2022
Accepted: 05 Jan 2022
ePublished: 01 Jul 2022
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