Arch Iran Med. 2022;25(8): 557-563.
doi: 10.34172/aim.2022.89

Scopus ID: 85143165196
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  PDF Download: 118


Original Article

Six-Month Follow-up of COVID-19 Patients: Mortality and Related Factors

Mohammad Haji Aghajani 1,2 ORCID logo, Mohammad Sistanizad 1,3, Amirmohammad Toloui 4, Arian Madani Neishaboori 4, Asma Pourhoseingholi 1, Ziba Asadpoordezaki 5,6, Reza Miri 1,2*, Mahmoud Yousefifard 4,7* ORCID logo

1 Prevention of Cardiovascular Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Department of Cardiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran
5 Department of Psychology, Maynooth University, Kildare, Ireland
6 Kathleen Lonsdale Institute for Human Health Research, Maynooth University, Kildare, Ireland
7 Pediatric Chronic Kidney Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran
*Corresponding Authors: Corresponding Author: Reza Miri, MD; Email: , Email: dr.rezamiri1@gmail.com; Corresponding Author: Mahmoud Yousefifard, MD; Email: , Email: yousefifard.m@iums.ac.ir


Background: Currently, there is lack of evidence regarding the long-term follow-up of coronavirus disease 2019 (COVID-19) patients. The aim of this study is to present a 6-month follow-up of COVID-19 patients who were discharged from hospital after their recovery.

Methods: This retrospective cohort study was performed to assess the six-month follow-up of COVID-19 patients who were discharged from the hospital between February 18 and July 20, 2020. The primary outcome was 6-month all-cause mortality.

Results: Data related to 614 patients were included to this study. Of these 614 patients, 48 patients died (7.8%). The cause of death in 26 patients (54.2%) was the relapse of COVID-19. Also, 44.2% of deaths happened in the first week after discharge and 74.4% in the first month. Risk factors of all-cause mortality included increase in age (odds ratio [OR]=1.09; P<0.001), increase in neutrophil percentage (OR=1.05; P=0.009) and increase in heart rate (OR=1.06; P=0.002) on the first admission. However, the risk of all-cause death was lower in patients who had higher levels of hematocrit (OR=0.93; P=0.021), oxygen saturation (OR=0.90; P=0.001) and mean arterial pressure (OR=0.93; P=0.001). In addition, increase in age (OR=1.11; P<0.001) was an independent risk factor for COVID-19-related death, while higher levels of lymphocyte percentage (OR=0.96; P=0.048), mean arterial pressure (OR=0.93; P=0.006) and arterial oxygen saturation (OR=0.91; P=0.009) were protective factors against COVID-19-related deaths during the 6-month period after discharge.

Conclusion: Death is relatively common in COVID-19 patients after their discharge from hospital. In light of our findings, we suggest that elderly patients who experience a decrease in their mean arterial pressure, oxygen saturation and lymphocyte count during their hospitalization, should be discharged cautiously. In addition, we recommend that one-month follow-up of discharged patients should be take place, and urgent return to hospital should be advised when the first signs of COVID-19 relapse are observed.

Cite this article as: Haji Aghajani M, Sistanizad M, Toloui A, Madani Neishaboori A, Pourhoseingholi A, Asadpoordezaki Z, et al. Six-month follow-up of Covid-19 patients: mortality and related factors. Arch Iran Med. 2022;25(8):557-563. doi: 10.34172/ aim.2022.89
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Submitted: 28 Apr 2021
Revision: 05 Sep 2021
Accepted: 22 Sep 2021
ePublished: 01 Aug 2022
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