Arch Iran Med. 2018;21(11): 536-543.
PMID: 30551695
Scopus ID: 85059282178
  Abstract View: 3090
  PDF Download: 1630


Experimental Endometriosis: Review of the Literature Through a Century and the Iranian Experience

Saeed Alborzi 1,2, Afshin Azimirad 1,2,3*, Mina Azimirad 4

1 Laparoscopy Research Center, Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran
2 Infertility Research Center, Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran
3 Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
4 Department of Nursing Science, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland
*Corresponding Author: Email: tafshina@gmail.com


Although endometriosis is not a newly discovered disease, it has still remained enigmatic. Understanding the pathophysiology of this disease is still one of the challenges of gynecology and reproductive medicine. Therefore, the subject of endometriosis treatment faces many questions to be answered. Even though this is not considered to be a rare disease, testing novel treatments on subjects is definitely contrary to medical ethics. This is where importance of animal studies is emphasized. History of animal studies on endometriosis dates back to the time when the young John Sampson presented his theory of retrograde flow of menstruation to the gynecologic society of his time to explain the mechanism of endometriosis. However, most of the medical society of that time favored metaplasia as the main mechanism over the new theory. In order to prove Sampson’s theory, animal models were used to induce endometriosis, and that was the first study of experimental endometriosis. Nowadays, although no one uses animals to evaluate Sampson theory of endometriosis, however, experimental endometriosis is widely used to study many different aspects of the disease from pathogenesis to possible options for treatments. Also, since then, various animals and different techniques have been proposed and so there is a huge body of literature on experimental endometriosis. Contrary to many countries, Iranian medical societies have neglected animal models for endometriosis until recently. This review article aims to go through the prominent articles on the subject and introduce different animals and methods to its readers and have a special look at Iranian literature on experimental endometriosis.

Cite this article as: Alborzi S, Azimirad A, Azimirad M. Experimental endometriosis: review of the literature through a century and the Iranian experience. Arch Iran Med. 2018;21(11):536–543.
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Submitted: 07 Mar 2018
Accepted: 07 Oct 2018
ePublished: 01 Nov 2018
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